| PYCARD |
| LOCUS ID | 29108 | ||||||||||
| GENE_SYMBOL | PYCARD | ||||||||||
| GENE NAME | PYD and CARD domain | ||||||||||
| SYNONYMNS | ASC TMS TMS1 CARD5 TMS-1 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 8307 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells u |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. ?Nlrp3?and?ASC?(Pycard) deficient mice were also protected against obesity-induced systemic metabolic dysregulation, as well as lipid accumulation and impaired insulin signaling in hepatic and cardiac tissues.? | 31379826 |