| RARRES2 |
| LOCUS ID | 5919 | |||||||||||||
| GENE_SYMBOL | RARRES2 | |||||||||||||
| GENE NAME | retinoic acid recept | |||||||||||||
| SYNONYMNS | TIG2,HP10433 | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 2167 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. High chemerin concentrations are significantly associated with renal impairment and predictive of cardiovascular events and that 15q15-23 might have an impact on chemerin levels beyond common genetic variations in RARRES2. | 26304698 |
| Insulin resistance and inflammation | 1. First, next to leptin, the circulating mediators chemerin, tissue inhibitor of metalloproteinase 1, EGF and TNF receptor 2 were identified as novel inflammatory mediators that are increased in childhood obesity. | 22806355 |