| Complication | Evidence | PMID |
| Cardiovascular | 1. This is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry. | 23755138 |
| Atherosclerosis | 1. BAC-Retn mice developed severe hepatic insulin resistance under chronic endotoxemia, accompanied by increased inflammatory responses in liver and skeletal muscle.Human resistin may link insulin resistance to inflammatory diseases such as obesity, type 2 diabetes, and atherosclerosis. 2. CONCLUSIONS: The adipose tissue-derived inflammatory factors resistin, vaspin and visfatin may be involved in the pathogenesis of atherosclerosis in elderly T2DM patients. | 21282361 |
| Dyslipidemia | 1. Furthermore, recent evidence suggests that resistin is associated with atherogenic dyslipidemia and hypertension. | 28192887 |
| Nephropathy | 1. The main determinants of resistin level in patients with T2DM are the level of renal function and inflammation rather than presence of microvascular complications, obesity and insulin resistance. | 29421824 |
| Insulin resistance and inflammation | 1. Although resistin can bind to toll-like receptor 4 (TLF4) activating proinflammatory responses in human and rodents, [3], [4], [5], [6], [7], [8] the inflammatory actions of resistin in human monocytes were found to be mediated by resistin binding to adenylyl cyclase-associated protein 1 (CAP1). | 31294061 |
