| RGN |
| LOCUS ID | 9104 | ||||||||||
| GENE_SYMBOL | RGN | ||||||||||
| GENE NAME | regucalcin | ||||||||||
| SYNONYMNS | RC, GNL, SMP30, HEL-S-41 | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 3437 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Regucalcin protein expression is reduced in DN kidney tissue and this significant change is reflected in exosomes isolated from urine. | 26072307 |