| RGS5 |
| LOCUS ID | 8490 | ||||||||||
| GENE_SYMBOL | RGS5 | ||||||||||
| GENE NAME | regulator of G prote | ||||||||||
| SYNONYMNS | MST092 MST106 MST129 MSTP032 MSTP092 MSTP106 MSTP129 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 2682 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript varian |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. RGS5 KO mice exhibited increased obesity, fat mass and ectopic lipid deposition in the liver compared with littermate control mice, regardless of diet. | 22272317 |