| RHOD |
| LOCUS ID | 29984 | ||||||||||
| GENE_SYMBOL | RHOD | ||||||||||
| GENE NAME | ras homolog family m | ||||||||||
| SYNONYMNS | Rho, ARHD, RHOM, RHOHP1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 22409 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dymics and reorganization of the actin cytoskeleton, and it may coordite membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provid |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1 alpha. The small GTPase Rho and its effector Rho-kinase are involved in the pathogenesis of diabetic nephropathy. Thus, we found a previously unrecognized renoprotective mechanism for the effects of Rho-kinase inhibition and this could be a potential therapeutic target for the treatment of diabetic nephropathy. 2. The RhoA-Rho kinase (ROCK) pathway contributes to a number of diabetic complications including cardiomyopathy and nephropathy. 3 . Rho kinase inhibition in diabetic nephropathy. 4. Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. 5. Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. 6. We conclude that suppression of the Rho/Rho-kinase pathway could be a new strategy for the treatment of diabetic nephropathy. 7. Rho kinase plays an important role in the development of diabetic nephropathy by inducing glomerular and tubulointerstitial fibrosis. | 23615507 |