| RIPK3 |
| LOCUS ID | 11035 | ||||||||||
| GENE_SYMBOL | RIPK3 | ||||||||||
| GENE NAME | receptor interacting | ||||||||||
| SYNONYMNS | RIP3 | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 31410 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-ka |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We provided mechanistic evidence that RIP3 knockdown attenuated hepatic dyslipidemia through preventing the expression of lipogenesis-associated genes. | 30599260 |