| RND3 |
| LOCUS ID | 390 | ||||||||||
| GENE_SYMBOL | RND3 | ||||||||||
| GENE NAME | Rho family GTPase 3 | ||||||||||
| SYNONYMNS | ARHE Rho8 RhoE memB | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 21074 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. By screening for RND3-dependent gene expression following siRNA-mediated RND3 knockdown in differentiating human adipocytes, we found downregulation of inflammatory genes and upregulation of genes related to adipocyte ipolysis and insulin signaling. | 31672447 |