| ROCK1 |
| LOCUS ID | 6093 | ||||||||||
| GENE_SYMBOL | ROCK1 | ||||||||||
| GENE NAME | Rho-associated, coil | ||||||||||
| SYNONYMNS | ROCK-I, P160ROCK | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 55899 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the ictive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy. Importantly, we found that ROCK1 triggers mitochondrial fission by phosphorylating Drp1 at serine 600 residue. These findings provide insights into the unexpected role of ROCK1 in a signaling cascade that regulates mitochondrial dymics. | 22326220 |