| ROCK2 |
| LOCUS ID | 9475 | ||||||||||
| GENE_SYMBOL | ROCK2 | ||||||||||
| GENE NAME | Rho associated coile | ||||||||||
| SYNONYMNS | ROCK-II | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 21010 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. both Rho kinase signaling and oxidative stress are involved in the pathogenesis of a number of human diseases, such as diabetes mellitus, hypertension, and atherosclerosis. | 25752964 |