| RORA |
| LOCUS ID | 6095 | ||||||||||
| GENE_SYMBOL | RORA | ||||||||||
| GENE NAME | RAR related orphan r | ||||||||||
| SYNONYMNS | ROR1 ROR2 ROR3 RZRA NR1F1 IDDECA RZR-ALPHA | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 56594 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the tr |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Adenovirus-mediated overexpression of ROR? or treatment with the ROR?-specific agonist SR1078 enhanced the expression of inflammatory cytokines and increased the number of infiltrated macrophages into adipose tissue. | 28698385 |