RORC
LOCUS ID6097
GENE_SYMBOLRORC
GENE NAMERAR related orphan r
SYNONYMNSTOR RORG RZRG IMD42 NR1F3 RZR-GAMMA
CHROMOSOME1
HOMOLOGENE ID21051
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcr

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Gene expression of NLRP3, CASPASE-1, CD3? (pan T cells), TBX21 (T(h)1 cells) and RORC (T(h)17 cells) was positively, whereas GATA3 (T(h)2 cells) was inversely correlated with AT inflammation. 22325453