| RORC |
| LOCUS ID | 6097 | ||||||||||
| GENE_SYMBOL | RORC | ||||||||||
| GENE NAME | RAR related orphan r | ||||||||||
| SYNONYMNS | TOR RORG RZRG IMD42 NR1F3 RZR-GAMMA | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 21051 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcr |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Gene expression of NLRP3, CASPASE-1, CD3? (pan T cells), TBX21 (T(h)1 cells) and RORC (T(h)17 cells) was positively, whereas GATA3 (T(h)2 cells) was inversely correlated with AT inflammation. | 22325453 |