| RPS6KB1 |
| LOCUS ID | 6198 | ||||||||||
| GENE_SYMBOL | RPS6KB1 | ||||||||||
| GENE NAME | ribosomal protein S6 | ||||||||||
| SYNONYMNS | S6K PS6K S6K1 STK14A p70-S6K p70 S6KA p70-alpha S6K-beta-1 p70(S6K)-alpha | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 81703 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular loc |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. RPS6KB1 mRNA levels in VAT were increased (P < 0.05) in obese patients. | 25118997 |