| RPTOR |
| LOCUS ID | 57521 | ||||||||||
| GENE_SYMBOL | RPTOR | ||||||||||
| GENE NAME | regulatory associate | ||||||||||
| SYNONYMNS | KOG1 Mip1 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 80210 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Macrophage Raptor deficiency reduced inflammatory gene expression in liver and adipose tissue, fatty liver and adipose tissue macrophage content in response to HFD. | 25120095 |