RUNX2
LOCUS ID860
GENE_SYMBOLRUNX2
GENE NAMErunt related transcr
SYNONYMNSCCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1
CHROMOSOME6
HOMOLOGENE ID68389
microRNAsNANA
GENE SUMMARY
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling.29930002