| RUNX2 |
| LOCUS ID | 860 | ||||||||||
| GENE_SYMBOL | RUNX2 | ||||||||||
| GENE NAME | runt related transcr | ||||||||||
| SYNONYMNS | CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 68389 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling. | 29930002 |