| S100A12 |
| LOCUS ID | 6283 | |||||||||||||
| GENE_SYMBOL | S100A12 | |||||||||||||
| GENE NAME | S100 calcium binding | |||||||||||||
| SYNONYMNS | p6, CAGC, CGRP, MRP6, CA | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 48361 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduct |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. High S100A12 levels are associated with the presence and severity of coronary artery disease (CAD) in patients with T2DM. | 23609464 |
| Retinopathy | 1. The plasma levels of S100A12 are closely associated with the presence of DR and might be a better biomarker for DR and the prediction of future macrovascular events. | 26132777 |