| S100B |
| LOCUS ID | 6285 | ||||||||||
| GENE_SYMBOL | S100B | ||||||||||
| GENE NAME | S100 calcium binding | ||||||||||
| SYNONYMNS | NEF S100 S100-B S100beta | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 4567 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extensi |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. S100B upregulated TNF-? and M1 markers in RAW (RAW264.7 macrophages), and TNF-? augmented S100B secretion from L1 (3T3-L1 adipocytes). | 23804363 |