| SAA1 |
| LOCUS ID | 6288 | |||||||||||||
| GENE_SYMBOL | SAA1 | |||||||||||||
| GENE NAME | serum amyloid A1 | |||||||||||||
| SYNONYMNS | SAA, PIG4, SAA2, TP53I4 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 128033 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzh |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. SAA and CRP baseline levels predicted development of micro- and macroalbuminuria during 30 years of follow up, supporting the theory that inflammation is involved in the progression of diabetic nephropathy. | 22885250 |
| Retinopathy | 1. Conditional logistic regression on matched paired data revealed that subjects in the top quartile for sTNFR-I (OR = 2.13), sTNFR-II (OR = 1.66), sgp130 (OR = 1.82), sIL6R (OR = 1.75), sVCAM1 (OR = 1.98), sICAM1 (OR = 2.23), CRP (OR = 2.40) and SAA (OR = 2.03), had the highest odds of having DR. | 26339132 |