| SCARB1 |
| LOCUS ID | 949 | ||||||||||
| GENE_SYMBOL | SCARB1 | ||||||||||
| GENE NAME | scavenger receptor c | ||||||||||
| SYNONYMNS | CLA1, SRB1, CLA-1, SR-BI, CD36L1, HDLQTL6 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 21132 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Previous studies in mice and humans have implicated the lipoprotein receptor SCARB1 in association with atherosclerosis and lipid levels. 2. Retention of low-density lipoprotein (LDL) cholesterol beneath the arterial endothelium initiates an inflammatory response culmiting in atherosclerosis." 3. Instead, LDL colocalized partially with the scavenger receptor SR-BI and overexpression of SR-BI increased LDL transcytosis; knockdown by siR significantly reduced it. | 25993026 |