| SECISBP2 |
| LOCUS ID | 79048 | ||||||||||
| GENE_SYMBOL | SECISBP2 | ||||||||||
| GENE NAME | SECIS binding protei | ||||||||||
| SYNONYMNS | SBP2 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 11415 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-spec |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. SBP2 in ATMs as a potential target in rescuing insulin resistance in obesity. | 31453320 |