| SENP1 |
| LOCUS ID | 29843 | ||||||||||
| GENE_SYMBOL | SENP1 | ||||||||||
| GENE NAME | SUMO specific peptid | ||||||||||
| SYNONYMNS | SuPr-2 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 8731 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Mechanistic studies show that SENP1 deletion in adipocytes enhances SUMOylation of the NF-?B essential molecule, NEMO, at lysine 277/309, leading to increased NF-?B activity, cytokine production and pancreatic inflammation. | 26596471 |