| SERPINF2 |
| LOCUS ID | 5345 | ||||||||||
| GENE_SYMBOL | SERPINF2 | ||||||||||
| GENE NAME | serpin peptidase inh | ||||||||||
| SYNONYMNS | AAP, API, PLI, A2AP, ALPHA-2-PI | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 719 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [prov |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The plasma concentrations of TM and plasmin-alpha 2-antiplasmin complex (PAP) were obviously increased in patients with diabetic nephropathy. | 11020468 |