| SFRP4 |
| LOCUS ID | 6424 | ||||||||||
| GENE_SYMBOL | SFRP4 | ||||||||||
| GENE NAME | secreted frizzled re | ||||||||||
| SYNONYMNS | PYL FRP-4 FRPHE FRZB-2 sFRP-4 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 2267 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Our study provides evidence that the concentrations of serum SFRP4 in T2DM and IGT subjects were increased and were correlated closely with glycose metabolic disorder, the first-phase of glucose-stimulated insulin secretion and chronic low-grade inflammation. | 26041556 |