| SGK1 |
| LOCUS ID | 6446 | ||||||||||
| GENE_SYMBOL | SGK1 | ||||||||||
| GENE NAME | serum/glucocorticoid | ||||||||||
| SYNONYMNS | SGK | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 48364 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several altertively spliced transcript variants encoding different isofo |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin(FN) expression in human mesangial cells, and this may be part of the mechanism of preventing and treating renal fibrosis of DN. | 20931854 |