| SHBG |
| LOCUS ID | 6462 | ||||||||||
| GENE_SYMBOL | SHBG | ||||||||||
| GENE NAME | sex hormone-binding | ||||||||||
| SYNONYMNS | ABP, SBP, TEBG | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 813 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Altertive splicing results in multiple trans |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. Low plasma SHBG levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 2. A less consistent pattern seen for the hormones in relation to CVD outcomes; non-smoking men showed a pattern of higher levels of total T, SHBG, and LH being negatively associated with IHD and less pronounced for stroke whereas in smokers higher levels of total T, free T, and LH were positively associated with the two CVD outcomes. | 26441241 |