| SIGLEC1 |
| LOCUS ID | 6614 | ||||||||||
| GENE_SYMBOL | SIGLEC1 | ||||||||||
| GENE NAME | sialic acid binding | ||||||||||
| SYNONYMNS | SN, CD169, SIGLEC-1, dJ1009E24.1 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 124458 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Altertive splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length ture of this variant |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The present findings suggest that sialoadhesin-positive macrophages may contribute to the progression of diabetic nephropathy. | 22526486 |