| SIRT3 |
| LOCUS ID | 23410 | ||||||||||
| GENE_SYMBOL | SIRT3 | ||||||||||
| GENE NAME | sirtuin 3 | ||||||||||
| SYNONYMNS | SIR2L3 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 81827 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We show that loss of FABP4/aP2 in macrophages additionally induces sirtuin 3 (SIRT3) expression and that monounsaturated fatty acids (C16:1, C18:1) lead to increased SIRT3 protein expression. | 26789108 |