| SLC2A2 |
| LOCUS ID | 6514 | ||||||||||
| GENE_SYMBOL | SLC2A2 | ||||||||||
| GENE NAME | solute carrier famil | ||||||||||
| SYNONYMNS | GLUT2 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 68047 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectiol glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Altertive splicing results in multiple transcript variants of |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Increased GLUT2 gene expression in the renal proximal tubule of diabetic rats is an adaptive condition, which may be important in the diabetic nephropathy development. | 15869838 |