SLC5A2
LOCUS ID6524
GENE_SYMBOLSLC5A2
GENE NAMEsolute carrier famil
SYNONYMNSSGLT2
CHROMOSOME16
HOMOLOGENE ID2289
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. In addition, several clinical studies have also shown that SGLT2 inhibitors could reduce blood pressure, body weight, serum uric acid levels and ameliorate cardiovascular risk in patients with diabetes. 2. RECENT FINDINGS: Several large CV outcome trials in patients with type 2 diabetes mellitus (T2DM) and with either established atherosclerotic CV disease (ASCVD) or at high risk for ASCVD reveal that SGLT2 inhibitors cause reductions in CV and HF endpoints.26228073
Atherosclerosis1. Inhibition of the sodium glucose co-transporter 2 (SGLT2) reduces cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) with atherosclerotic cardiovascular disease.30988077
Insulin resistance and inflammation1. We recently reported that the SGLT2 inhibitor empagliflozin increases fat utilization and browning in white adipose tissue and attenuates obesity-induced inflammation and insulin resistance by activating M2 macrophages.29376471