| SLC9A1 |
| LOCUS ID | 6548 | ||||||||||
| GENE_SYMBOL | SLC9A1 | ||||||||||
| GENE NAME | solute carrier famil | ||||||||||
| SYNONYMNS | APNH, NHE1, LIKNS, NHE-1, PPP1R143 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 20660 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a +/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Increased expression of Na(+)/H(+) exchanger (NHE) and Na(+),K(+)-ATPase activity have been demonstrated in diabetic nephropathy and are implicated in the development of hypertension | 20003708 |