| SMAD7 |
| LOCUS ID | 4092 | ||||||||||
| GENE_SYMBOL | SMAD7 | ||||||||||
| GENE NAME | SMAD family member 7 | ||||||||||
| SYNONYMNS | CRCS3, MADH7, MADH8 | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 4314 |
| microRNAs | miR-21 | 23292313 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this g |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1.MiRNA-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7. | 26415649 |