| SMG1 |
| LOCUS ID | 23049 | |||||||||||||
| GENE_SYMBOL | SMG1 | |||||||||||||
| GENE NAME | SMG1 phosphatidylino | |||||||||||||
| SYNONYMNS | ATX, LIP, 61E3.4 | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 56697 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Altertively spliced transcript variants have been described, but their full-length ture has yet to be determined. [provided by RefSeq, Mar 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy | 22864860 |
| Insulin resistance and inflammation | 1. Treatment of human adipose tissue with 10-1000 nM Dexamethasone decreased ATX secretion, increased LPP1 expression, and decreased mRNA expressions of IL-6, TNF-?, peroxisome proliferator-activated receptor (PPAR)-?, and adiponectin. | 30192654 |