SOCS1
LOCUS ID8651
GENE_SYMBOLSOCS1
GENE NAMEsuppressor of cytoki
SYNONYMNSJAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1
CHROMOSOME16
HOMOLOGENE ID2776
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine sigling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate c

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In vivo, intrarel delivery of adenovirus expressing SOCS1 and SOCS3 to diabetic rats significantly improved renal function and reduced renal lesions associated with diabetes, such as mesangial expansion, fibrosis, and influx of macrophages. Suppression of the JAK/STAT pathway by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy20185635
Tuberculosis1. We studied gene expression in peripheral blood cells of patients with diabetes (n = 10) and healthy endemic controls (EC, n = 11) both with and without MTB infection. Mycobacterial antigen (PPD) and mitogen-stimulated SOCS1, SOCS3, interferon-gamma (IFN-?), IL-6, and tumor necrosis factor alpha (TNF?) mRNA expression levels were determined using real-time polymerase chain reaction.28043584
Insulin resistance and inflammation1. SOCS1 LysM-Cre mice (SOCS1 floxed mice with mice expressing Cre recombinase under the control of the LysM-Cre promoter) had increased macrophage expression of CD11c, enhanced sensitivity to LPS, and palmitic acid and increased serum concentrations of tumor necrosis factor-?, interleukin-6, and monocyte chemoattractant protein.21646388