| SOCS2 |
| LOCUS ID | 8835 | ||||||||||
| GENE_SYMBOL | SOCS2 | ||||||||||
| GENE NAME | suppressor of cytoki | ||||||||||
| SYNONYMNS | CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 2880 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/sigl transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or sigl-transducing proteins via ubiquitition. The expression of |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Suppressor of cytokine signaling (SOCS) 2 has recently been indicated to be involved in the pathogenesis of DN, however, the exact regulatory mechanisms remain unclear. the present research demonstrates that SOCS2 reduces renal lesions associated with diabetes in rats. | 24802166 |