SOD2
LOCUS ID6648
GENE_SYMBOLSOD2
GENE NAMEsuperoxide dismutase
SYNONYMNSIPOB, MNSOD, MVCD6
CHROMOSOME6
HOMOLOGENE ID530
microRNAsNANA
GENE SUMMARY
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alterte transcriptiol splice variants, encodin

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Histone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression.23221071
Neuropathy1. DN was observed in the C57BL/6Jdb/db mouse, and decreased expression of SOD2 in these animals increased DN. Our data suggest that SOD2 activity is an important cellular modifier of neuronal oxidative defense against hyperglycemic injury.17927981
Nephropathy1. Conclusion:?Genetic variation in the?VEGFA?gene at the rs2010963 and rs69947 loci, the?ACE?gene at the rs4646994 locus, and the?SOD2?gene at the rs4880 locus may increase the risk of developing T2DN.31524543
Insulin resistance and Inflammation1. Weight loss was associated with an increase in IRAK3 and a decrease in SOD2, in association with a lowering of systemic inflammation and a decreasing number of metabolic syndrome components. 22272346