| SRC |
| LOCUS ID | 6714 | ||||||||||
| GENE_SYMBOL | SRC | ||||||||||
| GENE NAME | SRC proto-oncogene, | ||||||||||
| SYNONYMNS | ASV, SRC1, c-SRC, p60-Src | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 21120 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignt progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These data indicate a role for Src in a high glucose-Src-TACE-heparin-binding epidermal growth factor-EGFR-MAPK-sigling pathway to collagen accumulation. Thus, Src may provide a novel therapeutic target for diabetic nephropathy. | 23942551 |