| SREBF1 |
| LOCUS ID | 6720 | |||||||||||||
| GENE_SYMBOL | SREBF1 | |||||||||||||
| GENE NAME | sterol regulatory el | |||||||||||||
| SYNONYMNS | SREBP1, bHLHd1, SREBP-1c | |||||||||||||
| CHROMOSOME | 17 | |||||||||||||
| HOMOLOGENE ID | 3079 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mat |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Zhenqing recipe alleviates diabetic nephropathy in experimental type 2 diabetic rats through suppression of SREBP-1c. 2. These data suggest that activation of glomerular SREBP-1c could contribute to emergence and/or progression of diabetic nephropathy. 3. Our results indicate that in FVBdb/db mice, renal triglyceride and cholesterol accumulation is mediated by increased activity of SREBP-1 and -2. Increased expression of SREBPs plays an important role in causing renal lipid accumulation, glomerulosclerosis, tubulointerstitial fibrosis, and proteinuria in mice with type 2 diabetes. | 22564814 |
| Neuropathy | 1. This suggests that disturbed SREBP-1c regulated lipid metabolism may contribute to the pathophysiology of diabetic peripheral neuropathy. | 17632011 |