| STAT1 |
| LOCUS ID | 6772 | ||||||||||||||||
| GENE_SYMBOL | STAT1 | ||||||||||||||||
| GENE NAME | sigl transducer and | ||||||||||||||||
| SYNONYMNS | CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 | ||||||||||||||||
| CHROMOSOME | 2 | ||||||||||||||||
| HOMOLOGENE ID | 21428 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. SOCS gene delivery also decreased the activation of STAT1 and STAT3 and the expression of proinflammatory and profibrotic proteins in the diabetic kidney. these provide direct evidence for a link between the JAK/STAT/SOCS axis and hyperglycemia-induced cell responses in the kidney. Suppression of the JAK/STAT pathway by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy. | 20185635 |
| Cardiovascular | 1. STAT1 was significantly more expressed in D.CVD (p = 0.01) | 29739101 |
| Insulin resistance and inflammation | 1. High-throughput proteomic profiling and RNA-Seq suggested that miR-30a targets the transcription factor STAT1 to limit the actions of the proinflammatory cytokine interferon-? (IFN-?) that would otherwise restrict WAT expansion and decrease insulin sensitivity. | 30002134 |