| STAT3 |
| LOCUS ID | 6774 | ||||||||||||||||
| GENE_SYMBOL | STAT3 | ||||||||||||||||
| GENE NAME | signal transducer an | ||||||||||||||||
| SYNONYMNS | APRF, HIES, ADMIO | ||||||||||||||||
| CHROMOSOME | 17 | ||||||||||||||||
| HOMOLOGENE ID | 7960 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression o |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. SOCS gene delivery also decreased the activation of STAT1 and STAT3 and the expression of proinflammatory and profibrotic proteins in the diabetic kidney. In summary, these provide direct evidence for a link between the JAK/STAT/SOCS axis and hyperglycemia-induced cell responses in the kidney. Suppression of the JAK/STAT pathway by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy. | 20185635 |
| Retinopathy | 1. These suggest that simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3 | 18378570 |
| Insulin resistance and inflammation | 1. This effect was associated with the capacity of the drug to prevent IL-6-induced STAT3 phosphorylation on Tyr(705) and Ser(727) residues in vitro and in vivo. | 21617181 |