| STAT4 |
| LOCUS ID | 6775 | ||||||||||
| GENE_SYMBOL | STAT4 | ||||||||||
| GENE NAME | signal transducer an | ||||||||||
| SYNONYMNS | SLEB11 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 20679 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We have found that STAT4(-/-)C57Bl6/J mice develop high-fat diet-induced obesity (DIO) similar to wild-type controls, but that they have significantly improved insulin sensitivity and better glucose tolerance. | 23939393 |