| STEAP4 |
| LOCUS ID | 79689 | |||||||||||||
| GENE_SYMBOL | STEAP4 | |||||||||||||
| GENE NAME | STEAP4 metalloreduct | |||||||||||||
| SYNONYMNS | TIARP, STAMP2, TNFAIP9 | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 36422 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using D(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Altertive |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. STAMP2 overexpression could exert a protective effect on diabetic atherosclerosis by reducing IR and diminishing macrophage apoptosis. | 24467451 |
| Insulin resistance and inflammation | 1. In addition, hepatic STEAP4 expression is regulated by feeding and fasting, and obesity leads to the induction of STEAP4 expression in the liver. | 20304921 |