| STS |
| LOCUS ID | 412 | ||||||||||
| GENE_SYMBOL | STS | ||||||||||
| GENE NAME | steroid sulfatase | ||||||||||
| SYNONYMNS | ES ASC XLI ARSC SSDD ARSC1 | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 47918 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2 |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In defining the functional relevance of STS induction in metabolic disease, we showed that overexpression of STS in the liver of transgenic mice alleviated HFD and ob/ob models of obesity and type 2 diabetes, including reduced body weight, improved insulin sensitivity, and decreased hepatic steatosis and inflammation. | 24497646 |