| SUCNR1 |
| LOCUS ID | 56670 | ||||||||||
| GENE_SYMBOL | SUCNR1 | ||||||||||
| GENE NAME | succite receptor 1 | ||||||||||
| SYNONYMNS | GPR91 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 41865 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a G-protein-coupled receptor for succite, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Succinate accumulation in the local tissue environment and GPR91 signaling appear to be important early mechanisms by which cells detect and respond to hyperglycemia and trigger tissue injury in DN. Also, the distal nephron-collecting duct system, which is the major source of (pro)renin in diabetes and has the highest level of GPR91 expression in the kidney, may have an important, active, and early role in the pathogenesis of DN in contrast to the existing glomerulus-centric paradigm | 20861827 |