| SYNJ1 |
| LOCUS ID | 8867 | ||||||||||
| GENE_SYMBOL | SYNJ1 | ||||||||||
| GENE NAME | synaptojanin 1 | ||||||||||
| SYNONYMNS | synaptojanin 1 | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 48252 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. We identified four genes differentially expressed between the two study arms post-treatment, but not pre-treatment: GFRA2 (GDNF family receptor alpha-2), C1QBP (complement C1q binding protein), RAB35 (member of RAS oncogene family) and SYNJ1 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1). | 30221321 |