| TAB1 |
| LOCUS ID | 10454 | ||||||||||
| GENE_SYMBOL | TAB1 | ||||||||||
| GENE NAME | TGF-beta activated k | ||||||||||
| SYNONYMNS | 3'-Tab1 MAP3K7IP1 | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 4461 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Mechanistically, we revealed that TGF-?-activated kinase 1 (TAK1) and its adaptor protein TAK1 binding protein 1 (TAB1) played a dominant role in the regulatory effects of PGC-1?. We confirmed that PGC-1? inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 binding and TAK1 activation. | 26748475 |