| TBK1 |
| LOCUS ID | 29110 | ||||||||||
| GENE_SYMBOL | TBK1 | ||||||||||
| GENE NAME | TANK binding kinase | ||||||||||
| SYNONYMNS | NAK T2K IIAE8 FTDALS4 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 22742 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 20 |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The noncanonical I?B kinases IKK-? and TANK-binding kinase 1 (TBK1) are induced in liver and fat by NF-?B activation upon high-fat diet feeding and in turn initiate a program of counterinflammation that preserves energy storage. | 23396211 |