| TBX21 |
| LOCUS ID | 30009 | ||||||||||
| GENE_SYMBOL | TBX21 | ||||||||||
| GENE NAME | T-box transcription | ||||||||||
| SYNONYMNS | TBET T-PET T-bet TBLYM | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 8353 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IF |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. T-bet also directs T-cell homing to pro-inflammatory sites by the regulation of CXCR3 expression. | 24575371 |