TCF7L2
LOCUS ID6934
GENE_SYMBOLTCF7L2
GENE NAMEtranscription factor
SYNONYMNSTCF4, TCF-4
CHROMOSOME10
HOMOLOGENE ID7564
microRNAsNANA
GENE SUMMARY
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These results provide a new evidence that the TCF7L2/ALK1/Smad1 pathway plays a key role in the development of DN.20803090
Cardiovascular1. These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly associated with angiographically diagnosed Corory artery disease (CAD), specifically in patients with T2DM.21423583
Retinopathy1. Together, data from our study show that TCF7L2-rs7903146 is associated with Proliferative diabetic retinopathy (PDR) in Caucasian T2DM23434931
Atherosclerosis1. TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly associated with angiographically diagnosed CAD, specifically in patients with T2DM. TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis.21423583
Dyslipidemia1. The results revealed the important insights essential for the role of TCF7L2 that the T allele of TCF7L2 plays a significant role in the susceptibility to dyslipidemia, MetSyn, and T2D.21423583
Insulin resistance and inflammation1. Mechanistically, TCF-4 functioned as a co-activator of p65 to amplify the saturated free fatty acid (FFA)-stimulated promoter activity, mRNA transcription and secretion of proinflammatory cytokines in primary macrophages.28465699