TGFB1
LOCUS ID7040
GENE_SYMBOLTGFB1
GENE NAMEtransforming growth
SYNONYMNSCED, LAP, DPD1, TGFB, TGFbeta
CHROMOSOME19
HOMOLOGENE ID540
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TG

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We quantified the glomerular expression of thrombospondin-1 (THBS1, also known as TSP-1), transforming growth factor beta 1 (TGFB1, also known as TGF-beta1) and connective tissue growth factor (CTGF) at each stage of diabetic nephropathy. Increased glomerular expression of all three factors occurs from the earliest stage of diabetic nephropathy. 2. This study suggests that mast cells are involved in development of diabetic nephropathy. Through release of bioactive substances, such as tryptase, chymase, TGF-beta1, renin and TNF-alpha, into the tubular interstitium by degranulation, mast cells could promote renal inflammation and fibrosis, and thus contribute to diabetic nephropathy.16270194
Cardiovascular1. Although no serum or bone marrow inflammation was seen, HFS increased visceral fat, serum leptin and insulin at week 19 and induced further alterations in lipid profile, serum adiponectin, and TGFbeta1, TIMP1, MMP2, and MMP9, suggesting a prediabetic phenotype and cardiovascular dysfunction at week 27 more pronounced in M than G.26175082
Insulin resistance and inflammation1. TGFB1 expression was higher in NGT individuals than in individuals with type 2 diabetes (p=0.0303), and correlated with low fasting plasma insulin (p=0.0310, ? =-0.42).23595247