| TGM2 |
| LOCUS ID | 7052 | ||||||||||
| GENE_SYMBOL | TGM2 | ||||||||||
| GENE NAME | transglutaminase 2 | ||||||||||
| SYNONYMNS | TGC tTG G(h) hTG2 TG(C) | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 3391 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling. | 31165747 |